Proceedings of the National Academy of Sciences current issueProceedings of the National Academy of Sciences RSS feed -- current issueImmunology Immunochemical termination of self-tolerance- August 12, 2008 <p>The ability to selectively induce a strong immune response against self-proteins, or increase the immunogenicity of specific epitopes in foreign...http://www.pnas.org/cgi/content/short/105/32/11276?rss=1 Biochemistry Specific mutations within the AT-rich region of a plasmid replication origin affect either origin opening or helicase loading- August 12, 2008 <p>Prokaryotic and eukaryotic replicons possess a distinctive region containing a higher than average number of adenine and thymine residues (the...http://www.pnas.org/cgi/content/short/105/32/11134?rss=1 Genetics Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome- August 12, 2008 <p>DNA copy number variations (CNVs) are a significant and ubiquitous source of inherited human genetic variation. However, the importance of...http://www.pnas.org/cgi/content/short/105/32/11264?rss=1 Biochemistry Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis- August 12, 2008 The enzymatic activities of three proteins encoded by the thienamycin gene cluster of Streptomyces cattleya (ThnR, ThnH, and ThnT) have...http://www.pnas.org/cgi/content/short/105/32/11128?rss=1 Environmental_Sciences-BS From the Cover: Eutrophication of lakes cannot be controlled by reducing nitrogen input: Results of a 37-year whole-ecosyste- August 12, 2008 <p>Lake 227, a small lake in the Precambrian Shield at the Experimental Lakes Area (ELA), has been fertilized for 37...http://www.pnas.org/cgi/content/short/105/32/11254?rss=1 Biochemistry Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro- August 12, 2008 <p>The mitochondrial transcription machinery synthesizes the RNA primers required for initiation of leading-strand DNA synthesis in mammalian mitochondria. RNA primers...http://www.pnas.org/cgi/content/short/105/32/11122?rss=1 Developmental_Biology Pitx2 regulates gonad morphogenesis- August 12, 2008 <p>Organ shape and size, and, ultimately, organ function, relate in part to the cell and tissue spatial arrangement that takes...http://www.pnas.org/cgi/content/short/105/32/11242?rss=1 Biochemistry Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp- August 12, 2008 <p>DNA polymerases attach to the DNA sliding clamp through a common overlapping binding site. We identify a small-molecule compound that...http://www.pnas.org/cgi/content/short/105/32/11116?rss=1 Microbiology Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein- August 12, 2008 <p>Viruses remodel the host cell to optimize their replication both by delivery of virion proteins into the cell and by...http://www.pnas.org/cgi/content/short/105/32/11335?rss=1 Biophysics Crystal structure of the Agrobacterium virulence complex VirE1-VirE2 reveals a flexible protein that can accommodate different partners- August 12, 2008 Agrobacterium tumefaciens infects its plant hosts by a mechanism of horizontal gene transfer. This capability has led to its widespread...http://www.pnas.org/cgi/content/short/105/32/11170?rss=1 |