MedWorm: Gene TherapyMedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest headlines from journals and sites in the Gene Therapy category.Gene therapy for chronic pain gets first test in people- September 15, 2008 This week, University of Michigan scientists will begin a phase 1 clinical trial for the treatment of cancer-related pain, using a novel gene transfer vector injected into the skin to deliver a pain-relieving gene to the nervous system. (Source: Huliq Health News) MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.http://www.huliq.com/11/68465/gene-therapy-chronic-pain-gets-first-test-people Gene therapy for chronic pain gets first test in people- September 15, 2008 (University of Michigan Health System) University of Michigan scientists have launched a phase 1 clinical trial to test whether a pain-relieving gene can be sent to a key point in the nervous system and block pain sensation. The technique promises a more effective, targeted way to treat persistent pain than present painkillers. (Source: EurekAlert! - Cancer)http://www.eurekalert.org/pub_releases/2008-09/uomh-gtf091508.php Protein trans-splicing as a means for viral vector-mediated in vivo gene therapy- September 14, 2008 Human Gene Therapy , Vol. 0, No. 0: 1-8. Inteins catalyze protein splicing in a fashion similar to how self-splicing introns catalyze RNA splicing. Splitinteins catalyze precise ligation of two separate polypeptides through trans-splicing in a highly specific manner. Here we report a method of ... (Source: Human Gene Therapy)http://www.liebertonline.com/doi/abs/10.1089/hum.2008.009?ai=s5&mi=o0fy&af=R Adenovirus-mediated wild-type p53 expression suppresses growth of lung adeno-carcinoma cells- September 13, 2008 Abstract Objective: To study the growth suppression of lung adenocarcinoma cell by the introduction of wild-type P53 gene and explore a gene therapy approach for lung adenocarcinoma. Methods: A replication-deficient adenovirus vector encoding a wild-type P53 was constructed and transfected into the cultured human lung adenocarcinoma cell line GLC-82. The efficiency of gene transfection and expression was detected by immunochemical staining and polymerase chain reaction. The cell...http://www.springerlink.com/content/a826372h01v2660g/ Retroviral-mediated suicide gene therapy of experimental glioma- September 13, 2008 Abstract Objective: To establish a retroviral-mediated suicide gene therapy system for experimental glioma and test its efficacy. Methods: C6 rat glioma cells were infected with recombinant retrovirus containing HSV-tk gene. The C6tk cell line which stably expressed tk was selected and cloned. The sensitivities of C6tk cells to several nucleoside analogues, such as GCV, BVdU, ACV were compared by the growth inhibition studies. Antitumor effects were also observed after GCV...http://www.springerlink.com/content/qt965m0v7417w356/ Effect of mutant p27(kipl) gene on human cholangiocarcinoma cell line, qbc(939).- September 12, 2008 Related Articles Effect of mutant p27(kipl) gene on human cholangiocarcinoma cell line, QBC(939). World J Gastroenterol. 2008 Sep 14;14(34):5344-5348 Authors: Luo J, Chen YJ, Wang WY, Zou SQ AIM: To investigate the effects of exogenously mutated p27(kipl) (p27) on proliferation and apoptosis of human cholangiocarcinoma cell line, QBC(939)in vivo.METHODS: Adenviral vectors were used to transfect mutated p27 cDNA into human QBC(939)cell line. Expression of p27 was.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Ret... Advances in local targeted gene therapy for arthritis: towards clinical reality- September 12, 2008 Future Rheumatology , August 2008, Vol. 3, No. 4, Pages 307-309. (Source: Rheumatology)http://www.futuremedicine.com/doi/abs/10.2217/17460816.3.4.307?ai=sj&mi=2yyy&af=R Advances in local targeted gene therapy for arthritis: towards clinical reality- September 12, 2008 Future Rheumatology , August 2008, Vol. 3, No. 4, Pages 307-309. (Source: Future Rheumatology)http://www.futuremedicine.com/doi/abs/10.2217/17460816.3.4.307?ai=sj&mi=0&af=R Adenovirus-based vaccines generate cytotoxic t lymphocytes to epitopes of ns1 from dengue virus that are present in all major serotypes- September 12, 2008 Human Gene Therapy , Vol. 0, No. 0: 1-10. Dengue virus (DENV) infection is an expanding global threat to public health. Effective vaccine and treatment approaches remain elusive. B cell-directed vaccines may be complicated by an antibody-dependent enhancement (ADE) phenomenon based on cross-... (Source: Human Gene Therapy)http://www.liebertonline.com/doi/abs/10.1089/hum.2008.011?ai=s5&mi=o0fy&af=R Early immune response against retrovirally transduced herpes simplex virus thymidine kinase-expressing gene-modified t cells coinfused with a t cell-d- September 12, 2008 Human Gene Therapy , Vol. 0, No. 0: 1-14. Administration of herpes simplex thymidine kinase (HSV-tk)-expressing, gene-modified T cells (GMCs) with T cell-depleted bone marrow transplantation (TCD-BMT) can allow modulation of posttransplantation alloreactivity. Twelve patients received 2 105 to ... (Source: Human Gene Therapy)http://www.liebertonline.com/doi/abs/10.1089/hum.2007.156?ai=s5&mi=o0fy&af=R |