MedWorm: Gene TherapyMedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest headlines from journals and sites in the Gene Therapy category.Inhibition of nf-kappab in fusogenic membrane glycoprotein causing hl-60 cell death: implications for acute myeloid leukemia.- September 8, 2008 Related Articles Inhibition of NF-kappaB in fusogenic membrane glycoprotein causing HL-60 cell death: Implications for acute myeloid leukemia. Cancer Lett. 2008 Sep 8; Authors: Tan L, Jia H, Liu R, Wu J, Han H, Zuo Y, Yang S, Huang W Viral fusogenic membrane glycoproteins (FMGs) are new therapeutic genes for the control of tumor growth, the cellular mechanisms mediating cell death is non-apoptotic. However, the precise molecular mechanism remains to be...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Ret... Resistance of mature t cells to oncogene transformation- September 8, 2008 Leukemia caused by retroviral insertional mutagenesis after stem cell gene transfer has been reported in several experimental animals and in patients treated for X-linked severe combined immunodeficiency. Here, we analyzed whether gene transfer into mature T cells bears the same genotoxic risk. To address this issue in an experimental "worst case scenario," we transduced mature T cells and hematopoietic progenitor cells from C57BL6 (Ly5.1) donor mice with high copy numbers of gamma retroviral...http://bloodjournal.hematologylibrary.org/cgi/content/short/112/6/2278?rss=1 Adoptive immunotherapy for indolent non-hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous cd20-specific t cells- September 8, 2008 Adoptive immunotherapy with T cells expressing a tumor-specific chimeric T-cell receptor is a promising approach to cancer therapy that has not previously been explored for the treatment of lymphoma in human subjects. We report the results of a proof-of-concept clinical trial in which patients with relapsed or refractory indolent B-cell lymphoma or mantle cell lymphoma were treated with autologous T cells genetically modified by electroporation with a vector plasmid encoding a CD20-specific...http://bloodjournal.hematologylibrary.org/cgi/content/short/112/6/2261?rss=1 Tyrosine-modified pei: a novel and highly efficient vector for sirna delivery in mammalian cells- September 7, 2008 Delivery of synthetic small interfering RNA (siRNA) into cell remains the major obstacle to its biological activity. Cationic polymers, and in particular the "proton sponge" polyethylenimine (PEI), has shown promise for cancer gene therapy but appears inefficient for siRNA delivery. Here we report that modifying branched PEI with amino acids led to efficient siRNA delivery into mammalian cell lines, even in the presence of serum, and at dose as low as 1 nM. (Source: Nucleic Acids Symposium...http://nass.oxfordjournals.org/cgi/content/short/52/1/91?rss=1 Knockdown of rckp54 expression by rnai inhibits proliferation of human colorectal cancer cells in vitro and in vivo.- September 5, 2008 Related Articles Knockdown of RCKp54 expression by RNAi inhibits proliferation of human colorectal cancer cells in vitro and in vivo. Cancer Biol Ther. 2008 Oct 21;7(10) Authors: Lin F, Wang R, Shen JJ, Wang X, Gao P, Dong K, Zhang HZ Colorectal cancer is the third most common cancer in both men and women around the world. Although much progress of the mechanism of colorectal carcinogenesis has been made, the studies centering on the mechanisms of tumorigenesis..http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Ret... A homologous promoterless k-ras cdna targeting endogenous k-ras expression inhibits human pancreatic cancer cell growth in vitro and in vivo.- September 5, 2008 Related Articles A homologous promoterless K-ras cDNA targeting endogenous K-ras expression inhibits human pancreatic cancer cell growth in vitro and in vivo. Cancer Biol Ther. 2008 Oct 9;7(10) Authors: Ren XY, Liang ZY, Shi XH, Liu TH It has been reported that the local introduction of a promoterless DNA containing the complementary DNA (cDNA) sequence of a gene could induce gene-specific silencing in plants. The feasibility of this kind of silencing in human...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Ret... Gene therapy: some history, applications, problems, and prospects.- September 5, 2008 Related Articles Gene therapy: some history, applications, problems, and prospects. Toxicol Pathol. 2008;36(1):97-103 Authors: Cotrim AP, Baum BJ The concept of transferring genes to tissues for clinical applications has been discussed for nearly half a century, but our ability to manipulate genetic material via recombinant DNA technology has brought this goal to reality. While originally conceived as a way to treat life-threatening disorders (inborn errors,...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Ret... An approach to achieve long-term expression in skin gene therapy.- September 5, 2008 Related Articles An approach to achieve long-term expression in skin gene therapy. Toxicol Pathol. 2008;36(1):104-11 Authors: Therrien JP, Pf&xFC;tzner W, Vogel JC For gene therapy purposes, the skin is an attractive organ to target for systemic delivery of therapeutic proteins to treat systemic diseases, skin diseases, or skin cancer. To achieve long-term stable expression of a therapeutic gene in keratinocytes (KC), we have developed an approach using a...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Ret... Previous claims of sirna therapeutic effects called into question by report in human gene therapy- September 5, 2008 The many recent reports documenting the therapeutic efficacy of short interfering RNAs in animal models of human disease may actually be describing non-specific therapeutic effects related to the ability of siRNA to activate an immune response, according to a paper in Human Gene Therapy. (Source: ScienceDaily Headlines)http://feeds.sciencedaily.com/~r/sciencedaily/~3/383771388/080902171147.htm Transcriptional silencing of ets-1 efficiently suppresses angiogenesis of pancreatic cancer- September 5, 2008 Transcriptional silencing of ETS-1 efficiently suppresses angiogenesis of pancreatic cancer Cancer Gene Therapy advance online publication, September 5, 2008. doi:10.1038cgt.2008.65 Authors: L P Lefter, S Dima, M Sunamura, T Furukawa, Y Sato, M Abe, M Chivu, I Popescu & A Horii (Source: Cancer Gene Therapy)http://dx.doi.org/10.1038/cgt.2008.65 |