Nature Signaling Update

News and reviews about the latest in cell signaling research, brought to you by Nature Publishing Group.

Research Library: Internal dynamics control activation and activity of the autoinhibited Vav DH domain - (Found July 2, 2008 )

http://www.nature.com/doifinder/10.1038/nsmb.1428

Research Library: A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity - (Found July 2, 2008 )

http://www.nature.com/doifinder/10.1038/nchembio.90

News: Anesthetics worsen post-operative pain - (Found July 2, 2008 )

General anesthetics induce unconsciousness by activating GABA receptors. However, anesthetics can also stimulate TRP channels such as TRPA1 and TRPV1, which activate pain-sensing nerves throughout the body and may contribute to post-operative pain and inflammation.
http://www.nature.com/news/2008/080623/full/news.2008.909.html

Featured Article: IGF binding proteins: Make another little piece of my heart now, baby - (Found July 2, 2008 )

Insulin-like growth-factor-binding protein 4 (IGFBP-4) promotes cardiac development by binding to Wnt co-receptors and inhibiting canonical Wnt signaling.
http://www.signaling-gateway.org/update/featured/

Selected Update: Gene expression: Pioneering research - (Found July 2, 2008 )

mTOR and S6 protein kinase-1 (S6K1) help assemble an efficient initiation complex during the first round of translation on newly spliced mRNAs.
http://www.signaling-gateway.org/update/updates/200806/nrm2416.html

Selected Update: Cell polarity: APC throws the anchor - (Found July 2, 2008 )

APC (adenomatous polyposis coli) anchors over 50 mRNAs - including Rab13 and Pkp4 (plakophilin 4) - to microtubule plus ends at the pseudopodial tips of migrating cells.
http://www.signaling-gateway.org/update/updates/200806/nrc2413.html

Selected Update: Molecularly targeted therapy: JAK2 inhibitor restores balance in polycythaemia vera - (Found July 2, 2008 )

A highly specific ATP-competitive Janus kinase 2 (JAK2) inhibitor shows promise for treating myeloproliferative disorders such as polycythemia vera, essential thrombocythemia and myelofibrosis.
http://www.signaling-gateway.org/update/updates/200806/nrd2599.html

Research Library: STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle - (Found July 2, 2008 )

http://www.nature.com/doifinder/10.1038/ncb1731