Expert Opinion: Expert Opinion on Drug Metabolism & Toxicology: Table of ContentsTable of Contents for Expert Opinion on Drug Metabolism & Toxicology. List of articles from both the latest and ahead of print issues.Whole body physiologically-based pharmacokinetic models: their use in clinical drug development- August 25, 2008 Expert Opinion on Drug Metabolism & Toxicology , September 2008, Vol. 4, No. 9, Pages 1143-1152. Background: Whole-body physiologically-based pharmacokinetic (WB-PBPK) models mathematically describe an organism as a closed circulatory system consisting of compartments that represent the organs important for compound absorption, distribution, ...http://www.informapharmascience.com/doi/abs/10.1517/17425255.4.9.1143?ai=ss&mi=8iem&am... The use of inductively coupled plasma mass spectrometry as a detector in drug metabolism studies- August 25, 2008 Expert Opinion on Drug Metabolism & Toxicology , September 2008, Vol. 4, No. 9, Pages 1187-1207. Background: The inherent properties of element selectivity combined with high sensitivity and structure independent response, make inductively coupled plasma mass spectrometry (ICP-MS) an interesting alternative detection technique in drug metabolism ...http://www.informapharmascience.com/doi/abs/10.1517/17425255.4.9.1187?ai=ss&mi=8iem&am... Treatment of leishmaniasis with miltefosine: 2008 status- August 25, 2008 Expert Opinion on Drug Metabolism & Toxicology , September 2008, Vol. 4, No. 9, Pages 1209-1216. Background: Miltefosine is the first recognized oral treatment for leishmaniasis. It was first registered, in 2002, for Indian visceral leishmaniasis, and was reviewed by the present author in 2005. Question: Miltefosine is now being used for the full ...http://www.informapharmascience.com/doi/abs/10.1517/17425255.4.9.1209?ai=ss&mi=8iem&am... In silico prediction of substrate properties for ABC-multidrug transporters- August 25, 2008 Expert Opinion on Drug Metabolism & Toxicology , September 2008, Vol. 4, No. 9, Pages 1167-1180. Overexpression of ABC (ATP-binding cassette)-type drug efflux pumps, such as ABCB1, ABCC1 and ABCG2 in cancer cells confers multi-drug resistance (MDR) and represents a major cause of treatment failures in cancer therapy. Furthermore, there is increasing ...http://www.informapharmascience.com/doi/abs/10.1517/17425255.4.9.1167?ai=ss&mi=8iem&am... Pentostatin in chronic lymphocytic leukemia- August 25, 2008 Expert Opinion on Drug Metabolism & Toxicology , September 2008, Vol. 4, No. 9, Pages 1217-1222. Background: Chronic lymphocytic leukemia (CLL) is a disease that typically afflicts older individuals with a median age of diagnosis in the eighth decade of life for which treatments available now are not curative. Although purine analogue based ...http://www.informapharmascience.com/doi/abs/10.1517/17425255.4.9.1217?ai=ss&mi=8iem&am... Riluzole in psychiatry: a systematic review of the literature- August 25, 2008 Expert Opinion on Drug Metabolism & Toxicology , September 2008, Vol. 4, No. 9, Pages 1223-1234. Background: The glutamate system seems to be an important contributor to the pathophysiology of mood and anxiety disorders. Thus, glutamatergic modulators are reasonable candidate drugs to test in patients with mood and anxiety disorders. Riluzole, a ...http://www.informapharmascience.com/doi/abs/10.1517/17425255.4.9.1223?ai=ss&mi=8iem&am... Human cytochromes P450 in the metabolism of drugs: new molecular models of enzymesubstrate interactions- August 25, 2008 Expert Opinion on Drug Metabolism & Toxicology , September 2008, Vol. 4, No. 9, Pages 1181-1186. The overall predictive ability of molecular modelling, as applied to the cytochrome P450 (CYP) system, is analysed in the light of current developments in a variety of techniques, including X-ray crystallography, molecular biology, enzyme kinetics, ...http://www.informapharmascience.com/doi/abs/10.1517/17425255.4.9.1181?ai=ss&mi=8iem&am... Modifications of human carboxylesterase for improved prodrug activation- August 25, 2008 Expert Opinion on Drug Metabolism & Toxicology , September 2008, Vol. 4, No. 9, Pages 1153-1165. Background: Carboxylesterases (CEs) are ubiquitous enzymes responsible for the hydrolysis of numerous clinically useful drugs. As ester moieties are frequently included in molecules to improve their water solubility and bioavailability, de facto they ...http://www.informapharmascience.com/doi/abs/10.1517/17425255.4.9.1153?ai=ss&mi=8iem&am... Clinical development of metformin extended-release tablets for type 2 diabetes: an overview- August 25, 2008 Expert Opinion on Drug Metabolism & Toxicology , September 2008, Vol. 4, No. 9, Pages 1235-1243. Glumetza (Depomed, Inc., Menlo Park, CA, USA) is a recently approved gastric retentive extended-release formulation of metformin (M-ER) that provides effective, sustained and well-tolerated glycemic control with once daily administration. ...http://www.informapharmascience.com/doi/abs/10.1517/17425255.4.9.1235?ai=ss&mi=8iem&am... |