Breast Cancer Research - Latest articlesThe latest articles from Breast Cancer Research (ISSN 1465-5411) published by BioMed CentralSELDI-TOF proteomic profiling of breast carcinomas identifies clinicopathologically relevant groups of patients similar to previously defined clusters- June 30, 2008 Expression profiling and biomarker(s) discovery aim to provide means for tumour diagnosis, classification, therapy response and prognosis. The identification of novel markers could potentially lead to the building of robust early detection strategies, and personalised effective breast cancer therapies which would improve patient outcome. Recent evidence supports the hypothesis that genomic expression profiling using microarray analysis is a reliable method for breast cancer classification and..http://breast-cancer-research.com/content/10/3/107 PMC42, a breast progenitor cancer cell line, has normal-like mRNA and miRNA transcriptomes- June 27, 2008 IntroductionThe use of cultured cell lines as model systems for normal tissue is limited by the molecular alterations accompanying the immortalisation process, including changes in the mRNA and miRNA repertoire. Therefore, identification of cell lines with normal-like expression profiles is of paramount importance in studies of normal gene regulation. Methods: The mRNA and miRNA expression profiles of several breast cell lines of cancerous or normal origin were measured using printed slide...http://breast-cancer-research.com/content/10/3/R54 Mammographic density. Measurement of mammographic density- June 19, 2008 Mammographic density has been strongly associated with increased risk of breast cancer. Furthermore, density is inversely correlated with the accuracy of mammography and, therefore, a measurement of density conveys information about the difficulty of detecting cancer in a mammogram. Initial methods for assessing mammographic density were entirely subjective and qualitative; however, in the past few years methods have been developed to provide more objective and quantitative density...http://breast-cancer-research.com/content/10/3/209 CD44+CD24- phenotype is enriched in basal-like breast tumors- June 17, 2008 IntroductionHuman breast tumors are heterogeneous and consist of phenotypically diverse cells. Breast cancer cells with a CD44+CD24- phenotype have been suggested to have tumor-initiating properties with stem cell-like and invasive features, although it is unclear whether their presence within a tumor has clinical implications. There is also a large heterogeneity between tumors, illustrated by reproducible stratification into various subtypes based on gene expression profiles or...http://breast-cancer-research.com/content/10/3/R53 Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells- June 9, 2008 IntroductionThe identification of potential breast cancer stem cells is of importance as the characteristics of stem cells suggest that they are resistant to conventional forms of therapy. Several techniques have been proposed to isolate or enrich for tumorigenic breast cancer stem cells, including (a) culture of cells in non-adherent non-differentiating conditions to form mammospheres and (b) sorting of the cells by their surface phenotype (expression of CD24 and CD44). Methods: We have...http://breast-cancer-research.com/content/10/3/R52 Jab1 is a target of EGFR signaling in ER-negative breast cancer- June 6, 2008 Introductionc-Jun activation domain-binding protein-1 (Jab1) is a multifunctional signaling protein that previously has been shown to be a master regulator of a poor prognostic gene signature in invasive breast cancer and to mediate the action of S100A7. Since epidermal growth factor receptor (EGFR), like S100A7, is often expressed in estrogen receptor-alpha-negative (ER-) breast cancer, we set out to investigate the role of Jab1 in mediating EGFR signaling, another facet of the ER-...http://breast-cancer-research.com/content/10/3/R51 Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories- June 5, 2008 A woman typically presents for genetic counselling because she has a strong family history and is interested in knowing the probability she will develop disease in the future; that is, her absolute risk. Relative risk for a given factor refers to risk compared with either population average risk (sense a), or risk when not having the factor, with all other factors held constant (sense b). Not understanding that these are three distinct concepts can result in failure to correctly appreciate the..http://breast-cancer-research.com/content/10/3/208 Expression of the epidermal growth factor receptor (EGFR) and the phosphorylated EGFR in invasive breast carcinomas- June 3, 2008 IntroductionEpidermal growth factor receptor (EGFR) is involved in regulating cell growth in breast carcinomas. Its activated form, phosphorylated EGFR (pEGFR), is correlated with poor prognosis in lung cancer, but it has not yet been fully investigated in breast cancer. The aim of this study was to investigate the expressions of EGFR and pEGFR and their correlation with overall and disease-free survival, clinicopathological parameters and biological markers of invasion and angiogenesis...http://breast-cancer-research.com/content/10/3/R49 Mammary carcinoma behavior is programmed in the precancer stem cell- June 3, 2008 IntroductionThe "MINO" mouse model of ductal carcinoma in situ (DCIS) consists of six lines with distinct morphologic phenotypes and behavior each meeting experimentally defined criteria for "pre-cancer". Specifically, these lines grow orthotopically in cleared mammary fat pads and consistently progress to an invasive phenotype capable of ectopic growth. Transition to carcinoma has a consistent latency for each line and three of the lines also show pulmonary metastatic...http://breast-cancer-research.com/content/10/3/R50 |