Breast Cancer Research - Latest articlesThe latest articles from Breast Cancer Research (ISSN 1465-5411) published by BioMed CentralAlternative splicing and the progesterone receptor in breast cancer- May 30, 2008 Progesterone receptor status is a marker for hormone responsiveness and disease prognosis in breast cancer. Progesterone receptor negative tumours have generally been shown to have a poorer prognosis than progesterone receptor positive tumours. The observed loss of progesterone receptor could be through a range of mechanisms, including the generation of alternatively spliced progesterone receptor variants that are not detectable by current screening methods. Many progesterone receptor mRNA...http://breast-cancer-research.com/content/10/3/207 |