BMC Chemical Biology - Latest articlesThe latest articles from BMC Chemical Biology (ISSN 1472-6769) published by BioMed CentralIdentification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisia- January 7, 2008 Background: Sortin2 is a low mass compound that interferes with vacuolar delivery of proteins in plants and yeast. The Sortin2 phenotype was tested in Arabidopsis thaliana and found to be reversible upon drug removal, demonstrating the ability of chemical genomics to induce reversible phenotypes that would be difficult to achieve using conventional genetics 1. However, standard genetic methods can be used to identify drug target pathways in a high-throughput manner. Results: In this study, we...http://www.biomedcentral.com/1472-6769/8/1 |