Journal of Biology - Latest articlesThe latest articles from Journal of Biology (ISSN 1475-4924) published by BioMed CentralFunctions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy- February 28, 2008 The precise role of the O-fucosyltransferase Ofut1 in Notch-receptor trafficking has remained controversial. A recent study sheds new light on the non-catalytic activity of Ofut1 and provides further evidence that Ofut1 acts as a chaperone in the endoplasmic reticulum.http://jbiol.com/content/7/2/7 Reasons for breast cancer heterogeneity- February 22, 2008 Breast cancers differ in many ways, such as in their cell of origin, the molecular alterations causing them and the susceptibility and defenses of the patient, and this makes it difficult to give the most appropriate treatment. Two recent papers have contributed to the establishment of a more precise molecular classification of breast tumors.http://jbiol.com/content/7/2/6 |