Current Print IssueJournal of Experimental Medicine RSS feed -- current issueProteasomal degradation restricts the nuclear lifespan of AID- June 9, 2008 Activation-induced cytidine deaminase (AID) initiates all postrearrangement processes that diversify the immunoglobulin repertoire by specific deamination of cytidines at the immunoglobulin (Ig) locus. As uncontrolled expression of AID is potentially mutagenic, different types of regulation, particularly nucleocytoplasmic shuttling, restrict the likelihood of AID–deoxyribonucleic acid encounters. We studied additional mechanisms of regulation affecting the stability of the AID protein. No.http://www.jem.org/cgi/content/short/205/6/1357?rss=1 Balanced T cell subsets for good health- June 9, 2008http://www.jem.org/cgi/content/short/205/6/1246-a?rss=1 A crucial role for HVEM and BTLA in preventing intestinal inflammation- June 9, 2008 The interaction between the tumor necrosis factor (TNF) family member LIGHT and the TNF family receptor herpes virus entry mediator (HVEM) co-stimulates T cells and promotes inflammation. However, HVEM also triggers inhibitory signals by acting as a ligand that binds to B and T lymphocyte attenuator (BTLA), an immunoglobulin super family member. The contribution of HVEM interacting with these two binding partners in inflammatory processes remains unknown. In this study, we investigated the role.http://www.jem.org/cgi/content/short/205/6/1463?rss=1 Retraining macrophages to kill tumors- June 9, 2008http://www.jem.org/cgi/content/short/205/6/1247?rss=1 Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+IgD+CD27+ B cell repertoire in infants- June 9, 2008 T cell–dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell–independent responses. We used this dissociation to analyze the repertoire diversification of IgM+IgD+CD27+ B cells (also known as "IgM memory" B cells), comparing these cells with switched B cells in children <2 yr of age, with the aim of determining whether these two subsets are developmentally related. We show that the repertoire of IgM+IgD+CD27+ B cells in the spleen.http://www.jem.org/cgi/content/short/205/6/1331?rss=1 In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgammat+ T cells- June 9, 2008 The nuclear hormone receptor retinoic acid receptor–related orphan receptor t (RORt) is required for the generation of T helper 17 cells expressing the proinflammatory cytokine interleukin (IL)-17. In vivo, however, less than half of RORt+ T cells express IL-17. We report here that RORt+ Tβ cells include Foxp3+ cells that coexist with IL-17–producing RORt+ Tβ cells in all tissues examined. The Foxp3+ RORt+ Tβ express IL-10 and CCL20, and function as regulatory T...http://www.jem.org/cgi/content/short/205/6/1381?rss=1 Endothelial cells instigate sepsis- June 9, 2008http://www.jem.org/cgi/content/short/205/6/1247-b?rss=1 Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation- June 9, 2008 Recent in vitro studies have suggested a role for sialylation in chemokine receptor binding to its ligand (Bannert, N., S. Craig, M. Farzan, D. Sogah, N.V. Santo, H. Choe, and J. Sodroski. 2001. J. Exp. Med. 194:1661–1673). This prompted us to investigate chemokine-induced leukocyte adhesion in inflamed cremaster muscle venules of 2,3 sialyltransferase (ST3Gal-IV)-deficient mice. We found a marked reduction in leukocyte adhesion to inflamed microvessels upon injection of the CXCR2 ligands.http://www.jem.org/cgi/content/short/205/6/1435?rss=1 |