Current Print IssueJournal of Experimental Medicine RSS feed -- current issueVamsi Mootha: Taking an inventory of mitochondria- June 9, 2008http://www.jem.org/cgi/content/short/205/6/1248?rss=1 Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling- June 9, 2008 The mitogen-activated protein kinase (MAPK) pathway plays a critical role in Toll-like receptor (TLR) signaling. MAPK phosphatase-1 (MKP-1) inhibits the MAPK pathway and decreases TLR signaling, but the regulation of MKP-1 is not completely understood. We now show that MKP-1 is acetylated, and that acetylation regulates its ability to interact with its substrates and deactivate inflammatory signaling. We found that LPS activates acetylation of MKP-1. MKP-1 is acetylated by p300 on lysine...http://www.jem.org/cgi/content/short/205/6/1491?rss=1 Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsis- June 9, 2008http://www.jem.org/cgi/content/short/205/6/1509?rss=1 |