Journal of Experimental & Clinical Assisted Reproduction - Latest articlesThe latest articles from Journal of Experimental & Clinical Assisted Reproduction (ISSN 1743-1050) published by BioMed CentralA proposed mechanism for progesterone regulation of trophoblast MMP2 transcription independent of classical progesterone response elements on its prom- April 6, 2006 Background: Progesterone receptor act as ligand-inducible transcription factor in the respective target cells by binding to specific progesterone response elements in the promoter of the target genes. However, despite the lack of the classical progesterone response elements on matrix-metalloproteinase-2 promoter, progesterone has been shown to decrease the activity of this promoterPresentation of the hypothesisIt has recently been suggested that in addition to interacting with their classical...http://www.jexpclinassistreprod.com/content/3/1/4 |