Journal of Inflammation - Latest articlesThe latest articles from Journal of Inflammation (ISSN 1476-9255) published by BioMed CentralInhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor- February 27, 2008 Background: Farnesyltransferase inhibitors (FTI) are small molecule agents originally formulated to inhibit the oncogenic functions of Ras. Although subsequent analysis of FTI activity revealed wider effects on other pathways, the drug has been demonstrated to reduce Ras signaling by direct measurements. The purpose of the current study was to determine if FTI could be used to inhibit the inflammatory activities of a known Ras-activating human oncoprotein, RETPTC3. RETPTC3 is a fusion...http://www.journal-inflammation.com/content/5/1/3 Does CD4+CD25+foxp3+ cell (Treg) and IL-10 profile determine susceptibility to immune reconstitution inflammatory syndrome (IRIS) in HIV disease- February 18, 2008 HIV-specific T-lymphocyte responses that underlie IRIS are incomplete and largely remain hypothetical. Of the several mechanisms presented by the host to control host immunological damage, Treg cells are believed to play a critical role. Using the available experimental evidence, it is proposed that enormous synthesis of conventional FoxP3- Th cells (responsive) often renders subjects inherently vulnerable to IRIS, whereas that of natural FoxP3+ Treg cell synthesis predominate among subjects...http://www.journal-inflammation.com/content/5/1/2 |