Human Reproduction Update - current issueHuman Reproduction Update - RSS feed of current issueLysophospholipid signaling in the function and pathology of the reproductive system- August 12, 2008 BACKGROUND Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are two prominent signaling lysophospholipids (LPs) exerting their functions through a group of G protein-coupled receptors (GPCRs). This review covers current knowledge of the LP signaling in the function and pathology of the reproductive system. METHODS PubMed was searched up to May 2008 for papers on lysophospholipidsLPAS1PLPCSPC in combination with each part of the reproductive system, such as...http://humupd.oxfordjournals.org/cgi/content/short/14/5/519?rss=1 Effects of histamine and diamine oxidase activities on pregnancy: a critical review- August 12, 2008 BACKGROUND Histamine has been assumed to contribute to embryo–uterine interactions due to its vasoactive, differentiation and growth-promoting properties. However, its exact functions in pregnancy are unclear. The histamine-degrading enzyme diamine oxidase (DAO) is produced in high amounts by the placenta and has been supposed to act as a metabolic barrier to prevent excessive entry of bioactive histamine from the placenta into the maternal or fetal circulation. METHODS The literature...http://humupd.oxfordjournals.org/cgi/content/short/14/5/485?rss=1 Low dose aspirin and IVF: 'Is it time for a meta-analysis' continued- August 12, 2008http://humupd.oxfordjournals.org/cgi/content/short/14/5/537?rss=1 Functional genetic polymorphisms and female reproductive disorders: Part I: polycystic ovary syndrome and ovarian response- August 12, 2008 BACKGROUND The identification of polymorphisms associated with a disease can help to elucidate its pathogenesis, and this knowledge can be used to improve prognosis for women with a particular disorder, such as polycystic ovary syndrome (PCOS). Since an altered response to ovarian stimulation is also a characteristic of the disease, further knowledge about its aetiology could help in defining the parameters that determine the response of an individual to ovarian stimulation. METHODS PubMed and.http://humupd.oxfordjournals.org/cgi/content/short/14/5/459?rss=1 Potential significance of physiological and pharmacological glucocorticoids in early pregnancy- August 12, 2008 BACKGROUND Despite extensive studies of the developmental consequences of increased glucocorticoid exposure in mid- to late pregnancy, relatively little is known regarding the significance of glucocorticoids in early pregnancy. The objective of this review was to consider potential roles for this family of corticosteroids that might relate to early pregnancy. METHODS Although this is a narrative review, 249 source articles addressing potential effects of glucocorticoids on aspects of early...http://humupd.oxfordjournals.org/cgi/content/short/14/5/497?rss=1 The search for genes contributing to endometriosis risk- August 12, 2008 BACKGROUND Genetic variation contributes to the risk of developing endometriosis. This review summarizes gene mapping studies in endometriosis and the prospects of finding gene pathways contributing to disease using the latest genome-wide strategies. METHODS To identify candidate-gene association studies of endometriosis, a systematic literature search was conducted in PubMed of publications up to 1 April 2008, using the search terms ‘endometriosis’ plus ‘allele’ or...http://humupd.oxfordjournals.org/cgi/content/short/14/5/447?rss=1 Progesterone elevation and probability of pregnancy after IVF: facts and fiction- August 12, 2008http://humupd.oxfordjournals.org/cgi/content/short/14/5/538?rss=1 ART failure: oocyte contributions to unsuccessful fertilization- August 12, 2008 BACKGROUND The complexity of fertilization failure during assisted reproductive technologies (ART) is often under-appreciated, as this failure can occur at any number of essential mechanistic and cellular events. Importantly, successful fertilization is heavily dependent upon inherent qualities of the oocytes, and thus reliant upon fidelity of oocyte maturation. METHODS Pubmed and medline were searched up to April 2008 for papers on oocyte fertilization and its mechanistic components....http://humupd.oxfordjournals.org/cgi/content/short/14/5/431?rss=1 Psychological and social aspects of pregnancy, childbirth and early parenting after assisted conception: a systematic review- August 12, 2008 BACKGROUND It is known that infertility affects emotional well-being, satisfaction with life and self-esteem and that failed assisted reproductive technology (ART) treatment is associated with diminished life satisfaction, reduced self-confidence and substantial psychological distress. Investigations of whether these persist when treatment results in a pregnancy and live birth have been undertaken. METHODS A systematic search for English-language research articles on psychological and social...http://humupd.oxfordjournals.org/cgi/content/short/14/5/395?rss=1 Prevalence and diagnosis of congenital uterine anomalies in women with reproductive failure: a critical appraisal- August 12, 2008 BACKGROUND The prevalence of congenital uterine anomalies in women with reproductive failure remains unclear, largely due to methodological bias. The aim of this review is to assess the diagnostic accuracy of different methodologies and estimate the prevalence of congenital uterine anomalies in women with infertility and recurrent miscarriage (RM). METHODS Studies from 1950 to 2007 were identified through a MEDLINE search; all relevant references were further reviewed. RESULTS The most...http://humupd.oxfordjournals.org/cgi/content/short/14/5/415?rss=1 |