British Medical Bulletin - current issueBritish Medical Bulletin - RSS feed of current issueA review of Parkinson's disease- June 2, 2008 Introduction Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Sources of data Literature search using Medline with keywords Parkinson's disease supplemented with previously published papers known to the author. Areas of agreement There have been significant recent advances in the understanding of the pathogenesis of the disease. There has also been a greater realization that the disorder may be associated with significant non-motor disturbances in addition to...http://bmb.oxfordjournals.org/cgi/content/short/86/1/109?rss=1 Clinical applications of musculoskeletal tissue engineering- June 2, 2008 Background Current surgical techniques for the repair of the musculoskeletal system can be often limited by the availability, quality and quantity of materials, such as grafts to effect repair. This has led to the exploration and development of novel methods of intervention based on tissue engineering and regenerative medicine. Source of data This review summarizes the successes and investigations which are happening to date in the field of musculoskeletal tissue engineering. This is based on..http://bmb.oxfordjournals.org/cgi/content/short/86/1/7?rss=1 Turner syndrome and clinical treatment- June 2, 2008 Background Turner syndrome (TS) is a genetic disorder associated with abnormalities of the X chromosome, occurring in about 50 per 100 000 liveborn girls. TS is usually associated with reduced adult height, gonadal dysgenesis and thus insufficient circulating levels of female sex steroids leading to premature ovarian failure and infertility. The average intellectual performance is within the normal range. New insight into genetics, epidemiology, cardiology, endocrinology and metabolism from a...http://bmb.oxfordjournals.org/cgi/content/short/86/1/77?rss=1 Circadian abnormalities, molecular clock genes and chronobiological treatments in depression- June 2, 2008 Background A long-standing challenge in the treatment of depression is the development of a rapidly acting antidepressant. Conventional antidepressants typically require 2–8 weeks for clinical remission. In contrast, chronobiological interventions such as sleep deprivation treatment dramatically reduce depressive symptoms within 24–48 h in 40–60% of depressed subjects. It is hypothesized that fast-acting treatments for depression may alter circadian rhythms through...http://bmb.oxfordjournals.org/cgi/content/short/86/1/23?rss=1 Sports injuries in children- June 2, 2008 Introduction Sports injuries in children affect both growing bone and soft tissues, and can result in damage of growth mechanisms with subsequent lifelong, growth disturbance. This clinical review unfolds the incidence and distribution, physiology, injury characteristics and the prevention modalities. Methods A comprehensive in Medline literature search was performed, and the reference lists of sports injuries related journals and text books was consulted. Results During growth, there are...http://bmb.oxfordjournals.org/cgi/content/short/86/1/33?rss=1 Doping in competition or doping in sport- June 2, 2008 Introduction Since ancient times, competitive athletes have been familiar with the use of ergogenic aids and they will probably continue to use unfair and harmful substances in future, because their inclination to victory, along with the mirage of glory and money, will probably overcome health and legal risks. Sources of data We searched PubMed using the term doping over the period 1990 to the present day. We also included non-English journals. Areas of agreement By literature searching, it...http://bmb.oxfordjournals.org/cgi/content/short/86/1/95?rss=1 Type 2 diabetes in childhood: epidemiological and clinical aspects- June 2, 2008 Background The global obesity epidemic has raised concerns about the risk of a tide of Type 2 diabetes (T2DM) in childhood. This paper aims to review the recent data on the epidemiology of this problem as well as the clinical concerns. Sources of data A literature search was performed on Medline, and articles about childhood T2DM, in English and published from 2000 to 2008, were reviewed. Areas of agreement A review of 16 paediatric studies suggest that although T2DM is now more widely...http://bmb.oxfordjournals.org/cgi/content/short/86/1/59?rss=1 Update on the treatment of post-menopausal osteoporosis- June 2, 2008 Background Osteoporosis has a huge impact on public health, through the increased morbidity, mortality and economic costs associated with resultant fractures. The goal is to evaluate and identify those that are at risk of osteoporotic fracture in order to start preventative and therapeutic measures to reduce their risk of fracture. Sources of data This article reviews the data from randomized controlled trials for the current therapeutic agents available in the UK. It also reviews new trial...http://bmb.oxfordjournals.org/cgi/content/short/86/1/129?rss=1 |