BMC Medical Genetics - Latest articlesThe latest articles from BMC Medical Genetics (ISSN 1471-2350) published by BioMed CentralEvaluation of the association between the common E469K polymorphism in the ICAM-1 gene and diabetic nephropathy among type 1 diabetic patients in GoKi- May 27, 2008 Background: The ICAM-1 gene is a strong positional and biological candidate for susceptibility to the development of T1D and DN. We have recently demonstrated that SNP rs5498(E469K) confers susceptibility to the development of T1D and might be associated with DN in Swedish Caucasians. The present study aimed to further evaluate the association between the ICAM-1 genetic polymorphisms and DN. Methods: Two common non-synonymous SNPs, including rs5498(E469K) and rs1799969(R241G), in the ICAM-1...http://www.biomedcentral.com/1471-2350/9/47 |