Retrovirology - Latest articlesThe latest articles from Retrovirology (ISSN 1742-4690) published by BioMed CentralHighly diversified multiply drug-resistant HIV-1 quasispecies in PBMCs: a case report- May 30, 2008 Background: Although drug resistance is a major challenge in HIV therapy, the effect of drug resistance mutations on HIV evolution in vivo is not well understood. We have now investigated genetic heterogeneity in HIV-1 by performing drug resistance genotyping of the PR-RT regions of viruses derived from plasma and peripheral blood mononuclear cells (PBMCs) of a single patient who had failed multiple regimens of anti-retroviral therapy. Results: Patterns of drug resistance mutations showed that..http://www.retrovirology.com/content/5/1/43 |