Journal of Biology - Most viewed articlesMost viewed articles in last 30 days from Journal of Biology (ISSN 1475-4924) published by BioMed CentralCNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo- November 30, 2006 Background: Chemotherapy in cancer patients can be associated with serious short- and long-term adverse neurological effects, such as leukoencephalopathy and cognitive impairment, even when therapy is delivered systemically. The underlying cellular basis for these adverse effects is poorly understood. Results: We found that three mainstream chemotherapeutic agents carmustine (BCNU), cisplatin, and cytosine arabinoside (cytarabine), representing two DNA cross-linking agents and an...http://jbiol.com/content/5/7/22 |