Genes and DevelopmentGenes and Development recent publicationsProteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging.- (Found June 24, 2008 ) Publication Date: 2008 Jun 1 PMID: 18519635Authors: Morimoto, R. I.Journal: Genes DevThe long-term health of the cell is inextricably linked to protein quality control. Under optimal conditions this is accomplished by protein homeostasis, a highly complex network of molecular interactions that balances protein biosynthesis, folding, translocation, assemblydisassembly, and clearance. This review will examine the consequences of an imbalance in homeostasis on the flux of misfolded proteins that,..http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Lego clocks: building a clock from parts.- (Found June 24, 2008 ) Publication Date: 2008 Jun 1 PMID: 18519634Authors: Brunner, M. - Simons, M. J. - Merrow, M.Journal: Genes DevA new finding opens up speculation that the molecular mechanism of circadian clocks in Synechococcus elongatus is composed of multiple oscillator systems (Kitayama and colleagues, this issue, pp. 1513-1521), as has been described in many eukaryotic clock model systems. However, an alternative intepretation is that the pacemaker mechanism-as previously suggested-lies primarily in the...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... How ATR turns on: TopBP1 goes on ATRIP with ATR.- (Found June 24, 2008 ) Publication Date: 2008 Jun 1 PMID: 18519633Authors: Burrows, A. E. - Elledge, S. J.Journal: Genes DevIn this issue of Genes & Development, Mordes and colleagues (pp. 1478-1489) reveal intriguing mechanistic insights into activation of the ATR (ATM and Rad3-related) kinase critical for DNA damage resistance. They identify conserved regulatory domains within ATR and its binding partner ATRIP (ATR-interacting protein), which are contacted by the ATR activator TopBP1. These discoveries expand on...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Failure of CDKN2AB (INK4AB-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL.- (Found June 24, 2008 ) Publication Date: 2008 Jun 1 PMID: 18519632Authors: Mullighan, C. G. - Williams, R. T. - Downing, J. R. - Sherr, C. J.Journal: Genes DevDeletions of the CDKN2AB tumor suppressor locus and of the IKAROS and PAX5 genes that promote B-lineage development occur frequently in lymphoid, but not myeloid leukemias initiated by the BCR-ABL tyrosine kinase. Why is this the case, and how do these genetic lesions contribute to an aggressive disease that fails to durably respond to targeted kinase...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Trans-regulation of the expression of the transcription factor MtHAP2-1 by a uORF controls root nodule development.- (Found June 24, 2008 ) Publication Date: 2008 Jun 1 PMID: 18519645Authors: Combier, J. P. - de Billy, F. - Gamas, P. - Niebel, A. - Rivas, S.Journal: Genes DevMtHAP2-1 is a CCAAT-binding transcription factor from the model legume Medicago truncatula. We previously showed that MtHAP2-1 expression is regulated both spatially and temporally by microRNA169. Here we present a novel regulatory mechanism controlling MtHAP2-1 expression. Alternative splicing of an intron in the MtHAP2-1 5'leader sequence (LS) becomes...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Engineered telomere degradation models dyskeratosis congenita.- (Found June 24, 2008 ) Publication Date: 2008 Jun 11 PMID: 18550783Authors: Hockemeyer, D. - Palm, W. - Wang, R. C. - Couto, S. S. - de Lange, T.Journal: Genes DevDyskeratosis congenita (DC) is an inherited bone marrow failure syndrome characterized by cutaneous symptoms, including hyperpigmentation and nail dystrophy. Some forms of DC are caused by mutations in telomerase, the enzyme that counteracts telomere shortening, suggesting a telomere-based disease mechanism. However, mice with extensively shortened...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Tissue-specific regulation of SIRT1 by calorie restriction.- (Found June 24, 2008 ) Publication Date: 2008 Jun 11 PMID: 18550784Authors: Chen, D. - Bruno, J. - Easlon, E. - Lin, S. J. - Cheng, H. L. - Alt, F. W. - Guarente, L.Journal: Genes DevCalorie restriction (CR) has been reported to increase SIRT1 protein levels in mice, rats, and humans, and elevated activity of SIRT1 orthologs extends life span in yeast, worms, and flies. In this study, we challenge the paradigm that CR induces SIRT1 activity in all tissues by showing that activity of this sirtuin in the liver is, in...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... The anaphase-promoting complexcyclosome (APCC) is required for rereplication control in endoreplication cycles.- (Found June 24, 2008 ) Publication Date: 2008 Jun 15 PMID: 18559483Authors: Zielke, N. - Querings, S. - Rottig, C. - Lehner, C. - Sprenger, F.Journal: Genes DevEndoreplicating cells undergo multiple rounds of DNA replication leading to polyploidy or polyteny. Oscillation of Cyclin E (CycE)-dependent kinase activity is the main driving force in Drosophila endocycles. High levels of CycE-Cdk2 activity trigger S phase, while down-regulation of CycE-Cdk2 activity is crucial to allow licensing of replication origins. In...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo.- (Found June 24, 2008 ) Publication Date: 2008 Jun 15 PMID: 18559482Authors: Minella, A. C. - Loeb, K. R. - Knecht, A. - Welcker, M. - Varnum-Finney, B. J. - Bernstein, I. D. - Roberts, J. M. - Clurman, B. E.Journal: Genes DevPhosphorylations within N- and C-terminal degrons independently control the binding of cyclin E to the SCF(Fbw7) and thus its ubiquitination and proteasomal degradation. We have now determined the physiologic significance of cyclin E degradation by this pathway. We describe the construction of a..http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.- (Found June 24, 2008 ) Publication Date: 2008 Jun 15 PMID: 18559481Authors: Walkley, C. R. - Qudsi, R. - Sankaran, V. G. - Perry, J. A. - Gostissa, M. - Roth, S. I. - Rodda, S. J. - Snay, E. - Dunning, P. - Fahey, F. H. - Alt, F. W. - McMahon, A. P. - Orkin, S. H.Journal: Genes DevOsteosarcoma is the most common primary malignant tumor of bone. Analysis of familial cancer syndromes and sporadic cases has strongly implicated both p53 and pRb in its pathogenesis; however, the relative contribution of these mutations to.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... |