Genes and DevelopmentGenes and Development recent publicationsInterspecies variation reveals a conserved repressor of alpha-specific genes in Saccharomyces yeasts.- (Found June 24, 2008 ) Publication Date: 2008 Jun 15 PMID: 18559484Authors: Zill, O. A. - Rine, J.Journal: Genes DevThe mating-type determination circuit in Saccharomyces yeast serves as a classic paradigm for the genetic control of cell type in all eukaryotes. Using comparative genetics, we discovered a central and conserved, yet previously undetected, component of this genetic circuit: active repression of alpha-specific genes in a cells. Upon inactivation of the SUM1 gene in Saccharomyces bayanus, a close relative.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Mitotic CDKs control the metaphase-anaphase transition and trigger spindle elongation.- (Found June 24, 2008 ) Publication Date: 2008 Jun 1 PMID: 18519644Authors: Rahal, R. - Amon, A.Journal: Genes DevMitotic cyclin-dependent kinases (CDKs) control entry into mitosis, but their role during mitotic progression is less well understood. Here we characterize the functions of CDK activity associated with the mitotic cyclins Clb1, Clb2, and Clb3. We show that Clb-CDKs are important for the activation of the ubiquitin ligase Anaphase-Promoting ComplexCyclosome (APCC)-Cdc20 that triggers the metaphase-anaphase..http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen.- (Found June 24, 2008 ) Publication Date: 2008 Jun 1 PMID: 18519643Authors: Sathyanarayanan, S. - Zheng, X. - Kumar, S. - Chen, C. H. - Chen, D. - Hay, B. - Sehgal, A.Journal: Genes DevCircadian clocks regulate many different physiological processes and synchronize these to environmental light:dark cycles. In Drosophila, light is transmitted to the clock by a circadian blue light photoreceptor CRYPTOCHROME (CRY). In response to light, CRY promotes the degradation of the circadian clock protein TIMELESS (TIM) and then..http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Maternal noncoding transcripts antagonize the targeting of DNA elimination by scanRNAs in Paramecium tetraurelia.- (Found June 24, 2008 ) Publication Date: 2008 Jun 1 PMID: 18519642Authors: Lepere, G. - Betermier, M. - Meyer, E. - Duharcourt, S.Journal: Genes DevThe germline genome of ciliates is extensively rearranged during the development of a new somatic macronucleus from the germline micronucleus, after sexual events. In Paramecium tetraurelia, single-copy internal eliminated sequences (IESs) are precisely excised from coding sequences and intergenic regions. For a subset of IESs, introduction of the IES sequence into the...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Akt-dependent regulation of NF-kappaB is controlled by mTOR and Raptor in association with IKK.- (Found June 24, 2008 ) Publication Date: 2008 Jun 1 PMID: 18519641Authors: Dan, H. C. - Cooper, M. J. - Cogswell, P. C. - Duncan, J. A. - Ting, J. P. - Baldwin, A. S.Journal: Genes DevWhile NF-kappaB is considered to play key roles in the development and progression of many cancers, the mechanisms whereby this transcription factor is activated in cancer are poorly understood. A key oncoprotein in a variety of cancers is the serine-threonine kinase Akt, which can be activated by mutations in PI3K, by loss of...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.- (Found June 24, 2008 ) Publication Date: 2008 Jun 1 PMID: 18519640Authors: Mordes, D. A. - Glick, G. G. - Zhao, R. - Cortez, D.Journal: Genes DevThe ATR (ATM and Rad3-related) kinase and its regulatory partner ATRIP (ATR-interacting protein) coordinate checkpoint responses to DNA damage and replication stress. TopBP1 functions as a general activator of ATR. However, the mechanism by which TopBP1 activates ATR is unknown. Here, we show that ATRIP contains a TopBP1-interacting region that is necessary for the...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... VACTERLcaudal regressionCurrarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5.- (Found June 24, 2008 ) Publication Date: 2008 Jun 1 PMID: 18519639Authors: Szumska, D. - Pieles, G. - Essalmani, R. - Bilski, M. - Mesnard, D. - Kaur, K. - Franklyn, A. - El Omari, K. - Jefferis, J. - Bentham, J. - Taylor, J. M. - Schneider, J. E. - Arnold, S. J. - Johnson, P. - Tymowska-Lalanne, Z. - Stammers, D. - Clarke, K. - Neubauer, S. - Morris, A. - Brown, S. D. - Shaw-Smith, C. - Cama, A. - Capra, V. - Ragoussis, J. - Constam, D. - Seidah, N. G. - Prat, A. - Bhattacharya, S.Journal: Genes DevWe have...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.- (Found June 24, 2008 ) Publication Date: 2008 Jun 1 PMID: 18519638Authors: Nishitoh, H. - Kadowaki, H. - Nagai, A. - Maruyama, T. - Yokota, T. - Fukutomi, H. - Noguchi, T. - Matsuzawa, A. - Takeda, K. - Ichijo, H.Journal: Genes DevMutation in CuZn-superoxide dismutase (SOD1) is a cause of familial amyotrophic lateral sclerosis (ALS). Mutant SOD1 protein (SOD1(mut)) induces motor neuron death, although the molecular mechanism of SOD1(mut)-induced cell death remains controversial. Here we show that SOD1(mut)...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas.- (Found June 24, 2008 ) Publication Date: 2008 Jun 1 PMID: 18519637Authors: Dong, P. D. - Provost, E. - Leach, S. D. - Stainier, D. Y.Journal: Genes DevThe mechanisms regulating pancreatic endocrine versus exocrine fate are not well defined. By analyzing the effects of Ptf1a partial loss of function, we uncovered novel roles for this transcription factor in determining pancreatic fates. In a newly identified hypomorphic ptf1a mutant, pancreatic cells that would normally express ptf1a and become exocrine cells, express.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.- (Found June 24, 2008 ) Publication Date: 2008 Jun 1 PMID: 18519636Authors: Xue, W. - Krasnitz, A. - Lucito, R. - Sordella, R. - Vanaelst, L. - Cordon-Cardo, C. - Singer, S. - Kuehnel, F. - Wigler, M. - Powers, S. - Zender, L. - Lowe, S. W.Journal: Genes DevDeletions on chromosome 8p are common in human tumors, suggesting that one or more tumor suppressor genes reside in this region. Deleted in Liver Cancer 1 (DLC1) encodes a Rho-GTPase activating protein and is a candidate 8p tumor suppressor. We show that DLC1...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... |