Genes and DevelopmentGenes and Development recent publicationsPhosphatidic acid mediates demyelination in Lpin1 mutant mice.- (Found June 24, 2008 ) Publication Date: 2008 Jun 15 PMID: 18559480Authors: Nadra, K. - Charles, A. S. - Medard, J. J. - Hendriks, W. T. - Han, G. S. - Gres, S. - Carman, G. M. - Saulnier-Blache, J. S. - Verheijen, M. H. - Chrast, R.Journal: Genes DevLipids play crucial roles in many aspects of glial cell biology, affecting processes ranging from myelin membrane biosynthesis to axo-glial interactions. In order to study the role of lipid metabolism in myelinating glial cells, we specifically deleted in Schwann cells...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion.- (Found June 24, 2008 ) Publication Date: 2008 Jun 15 PMID: 18559479Authors: Baxt, L. A. - Baker, R. P. - Singh, U. - Urban, S.Journal: Genes DevRhomboid proteases are membrane-embedded enzymes conserved in all kingdoms of life, but their cellular functions across evolution are largely unknown. Prior work has uncovered a role for rhomboid enzymes in host cell invasion by malaria and related intracellular parasites, but this is unlikely to be a widespread function, even in pathogens, since rhomboid proteases are also...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice.- (Found June 24, 2008 ) Publication Date: 2008 Jun 15 PMID: 18559478Authors: Kurimoto, K. - Yabuta, Y. - Ohinata, Y. - Shigeta, M. - Yamanaka, K. - Saitou, M.Journal: Genes DevSpecification of germ cell fate is fundamental in development. With a highly representative single-cell microarray and rigorous quantitative PCR analysis, we defined the genome-wide transcription dynamics that create primordial germ cells (PGCs) from the epiblast, a process that exclusively segregates them from their somatic neighbors. We also...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development.- (Found June 24, 2008 ) Publication Date: 2008 Jun 15 PMID: 18559477Authors: Hirasawa, R. - Chiba, H. - Kaneda, M. - Tajima, S. - Li, E. - Jaenisch, R. - Sasaki, H.Journal: Genes DevParental origin-specific DNA methylation regulates the monoallelic expression of the mammalian imprinted genes. The methylation marks or imprints are established in the parental germline and maintained throughout embryonic development. However, it is unclear how the methylation imprints are maintained through extensive demethylation in...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Tandem repeats upstream of the Arabidopsis endogene SDC recruit non-CG DNA methylation and initiate siRNA spreading.- (Found June 24, 2008 ) Publication Date: 2008 Jun 15 PMID: 18559476Authors: Henderson, I. R. - Jacobsen, S. E.Journal: Genes DevPlants use siRNAs to target cytosine DNA methylation to both symmetrical CG and nonsymmetrical (CHG and CHH) sequence contexts. DNA methylation and siRNA clusters most frequently overlap with transposons in the Arabidopsis thaliana genome. However, a significant number of protein-coding genes also show promoter DNA methylation, and this can be used to silence their expression. Loss of the...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis.- (Found June 24, 2008 ) Publication Date: 2008 Jun 15 PMID: 18559475Authors: Sokol, N. S. - Xu, P. - Jan, Y. N. - Ambros, V.Journal: Genes DevThe Drosophila let-7-Complex (let-7-C) is a polycistronic locus encoding three ancient microRNAs: let-7, miR-100, and fly lin-4 (miR-125). We find that the let-7-C locus is principally expressed in the pupal and adult neuromusculature. let-7-C knockout flies appear normal externally but display defects in adult behaviors (e.g., flight, motility, and fertility) as well as clear...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Mitochondrial dynamics and apoptosis.- (Found June 24, 2008 ) Publication Date: 2008 Jun 15 PMID: 18559474Authors: Suen, D. F. - Norris, K. L. - Youle, R. J.Journal: Genes DevIn healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting network. The molecular machinery that mediates this organelle fission and fusion is necessary to maintain mitochondrial integrity, perhaps by facilitating DNA or protein quality control. This network disintegrates during apoptosis at the time of cytochrome c release and prior to caspase...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... A matter of timing: microRNA-controlled temporal identities in worms and flies.- (Found June 24, 2008 ) Publication Date: 2008 Jun 15 PMID: 18559473Authors: Frasch, M.Journal: Genes DevThe first microRNAs were identified in Caenorhabditis elegans based on their functions in the temporal regulation of stage-specific cell fate decisions. Until now, it was not known whether the so-called heterochronic genes that encode miRNAs are also involved in controlling developmental transitions in other organisms. New findings by Sokol et al. (this issue of Genes & Development, pp. 1591-1596) demonstrate that..http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Safeguarding parental identity: Dnmt1 maintains imprints during epigenetic reprogramming in early embryogenesis.- (Found June 24, 2008 ) Publication Date: 2008 Jun 15 PMID: 18559472Authors: Branco, M. R. - Oda, M. - Reik, W.Journal: Genes DevDuring early mammalian embryogenesis, the genome undergoes global epigenetic reprogramming, losing most of its methylation before re-establishing it de novo at implantation. However, faithful maintenance of methylation at imprinted genes during this process is vital for embryonic development, but the DNA methyltransferase responsible for this maintenance has remained unknown. In this issue...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... Intriguing parasites and intramembrane proteases.- (Found June 24, 2008 ) Publication Date: 2008 Jun 15 PMID: 18559471Authors: Rawson, R. B.Journal: Genes DevRhomboid intramembrane proteases occur throughout the kingdoms of life. In this issue of Genes & Development, Baxt and colleagues (pp. 1636-1646) report that the single proteolytic rhomboid (EhROM1) from Entamoeba histolytica cleaves cell surface galactose-binding or N-acetylgalactosamine-binding (GalGal-NAc) lectins. EhROM1 and lectins colocalize during phagocytosis and receptor capping. EhROM1 is found at the..http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract... |