BMC Pharmacology - Latest articlesThe latest articles from BMC Pharmacology (ISSN 1471-2210) published by BioMed CentralRole of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats- February 20, 2008 Background: Seaweeds or marine algae have long been made up a key part of the Asian diet, and as an antioxidant, sulphated polysaccharides have piqued the interest of many researchers as one of the ocean's greatest treasures. The present investigation suggests the therapeutic potential of sulphated polysaccharides from marine brown algae "Sargassum wightii" in Cyclosporine A (CsA)- induced liver injury. CsA is a potent immunosuppressive agent used in the field of organ...http://www.biomedcentral.com/1471-2210/8/4 Inhibition of 11HSD1 with the S-phenylethylaminothiazolone BVT116429 increases adiponectin concentrations and improves glucose homeostasis in diabetic- February 12, 2008 Background: A substantial body of evidence indicates that reduced plasma adiponectin levels may be key in the development of insulin resistance, type 2 diabetes and the metabolic syndrome. Glucocorticoids decrease the levels of adiponectin in animals and humans. Cortisone is transformed to its active form cortisol, via 11-hydroxysteroid dehydrogenase (HSD) type 1. This study sought to ascertain if inhibition of 11 HSD1 with a new selective inhibitor, BVT116429, affects the concentrations of...http://www.biomedcentral.com/1471-2210/8/3 |