Proceedings of the National Academy of Sciences current issueProceedings of the National Academy of Sciences RSS feed -- current issueMicrobiology A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea- August 12, 2008 Saccharopolyspora erythraea makes erythromycin, an antibiotic commonly used in human medicine. Unusually, the erythromycin biosynthetic (ery) cluster lacks a pathway-specific...http://www.pnas.org/cgi/content/short/105/32/11346?rss=1 Cell_Biology Promoter ChIP-chip analysis in mouse testis reveals Y chromosome occupancy by HSF2- August 12, 2008 <p>The mammalian Y chromosome is essential for spermatogenesis, which is characterized by sperm cell differentiation and chromatin condensation for acquisition...http://www.pnas.org/cgi/content/short/105/32/11224?rss=1 Psychology-BS Electrophysiological evidence of illusory audiovisual speech percept in human infants- August 12, 2008 <p>How effortlessly and quickly infants acquire their native language remains one of the most intriguing questions of human development. Our...http://www.pnas.org/cgi/content/short/105/32/11442?rss=1 Cell_Biology A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators- August 12, 2008 <p>Alternative splicing has emerged as a promising therapeutic target in a number of human disorders. However, the discovery of compounds...http://www.pnas.org/cgi/content/short/105/32/11218?rss=1 Physiology Nitric oxide promotes distant organ protection: Evidence for an endocrine role of nitric oxide- August 12, 2008 <p>Endothelial NOS (eNOS)-derived NO has long been considered a paracrine signaling molecule only capable of affecting nearby cells because of...http://www.pnas.org/cgi/content/short/105/32/11430?rss=1 Cell_Biology The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity- August 12, 2008 Genetic studies have shown that ubiquitination and endocytosis of the Drosophila ligand Delta in signal-sending cells are required for activation...http://www.pnas.org/cgi/content/short/105/32/11212?rss=1 Physiology Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes- August 12, 2008 <p>In this study, we demonstrate that fluid shear stress (FSS)-induced actin cytoskeletal reorganization and junctional formation in renal epithelial cells...http://www.pnas.org/cgi/content/short/105/32/11418?rss=1 Cell_Biology AIMP2p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53- August 12, 2008 <p>AIMP2p38 is a scaffolding protein required for the assembly of the macromolecular tRNA synthetase complex. Here, we describe a previously...http://www.pnas.org/cgi/content/short/105/32/11206?rss=1 Neuroscience Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice- August 12, 2008 <p>Agrin and its receptor MuSK are required for the formation of the postsynaptic apparatus at the neuromuscular junction (NMJ). In...http://www.pnas.org/cgi/content/short/105/32/11406?rss=1 Cell_Biology MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks- August 12, 2008 <p>The product of the Nijmegen breakage syndrome gene (NBS1) plays crucial roles in DNA damage response through its association with...http://www.pnas.org/cgi/content/short/105/32/11200?rss=1 |