Proceedings of the National Academy of Sciences current issueProceedings of the National Academy of Sciences RSS feed -- current issueNeuroscience Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation- August 12, 2008 <p>Mice deficient in cholesterol 24-hydroxylase exhibit reduced rates of cholesterol synthesis and other non-sterol isoprenoids that arise from the mevalonate...http://www.pnas.org/cgi/content/short/105/32/11394?rss=1 Biophysics Ion permeation through a Cl--selective channel designed from a CLC Cl-H+ exchanger- August 12, 2008 The CLC family of Cl–-transporting proteins includes both Cl– channels and Cl–H+ exchange transporters. CLC-ec1, a structurally known bacterial homolog...http://www.pnas.org/cgi/content/short/105/32/11194?rss=1 Neuroscience The Fezf2-Ctip2 genetic pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortex- August 12, 2008 <p>Pyramidal neurons in the deep layers of the cerebral cortex can be classified into two major classes: callosal projection neurons...http://www.pnas.org/cgi/content/short/105/32/11382?rss=1 Biophysics Experimental approaches to kinetics of gas diffusion in hydrogenase- August 12, 2008 Hydrogenases, which catalyze H2 to H+ conversion as part of the bioenergetic metabolism of many microorganisms, are among the metalloenzymes...http://www.pnas.org/cgi/content/short/105/32/11188?rss=1 Neuroscience Polarized microtubule arrays in apical dendrites and axons- August 12, 2008 The polarization of microtubules within neurons in vivo is crucial in their role of determining the directions and speeds of...http://www.pnas.org/cgi/content/short/105/32/11370?rss=1 Biophysics Dynamic energy landscape view of coupled binding and protein conformational change: Induced-fit versus population-shift mechanisms- August 12, 2008 <p>Allostery, the coupling between ligand binding and protein conformational change, is the heart of biological network and it has often...http://www.pnas.org/cgi/content/short/105/32/11182?rss=1 Neuroscience Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis- August 12, 2008 <p>The interplay between demyelination and remyelination is critical in the progress of multiple sclerosis (MS) and its animal model, experimental...http://www.pnas.org/cgi/content/short/105/32/11358?rss=1 Biophysics Orientation dependence in fluorescent energy transfer between Cy3 and Cy5 terminally attached to double-stranded nucleic acids- August 12, 2008 <p>We have found that the efficiency of fluorescence resonance energy transfer between Cy3 and Cy5 terminally attached to the 5'...http://www.pnas.org/cgi/content/short/105/32/11176?rss=1 Cell_Biology DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1- August 12, 2008 <p>The cell cycle transcriptional program imposes order on events of the cell-cycle and is a target for signals that regulate...http://www.pnas.org/cgi/content/short/105/32/11230?rss=1 Biochemistry Structural basis for induced formation of the inflammatory mediator prostaglandin E2- August 12, 2008 <p>Prostaglandins (PG) are bioactive lipids produced from arachidonic acid via the action of cyclooxygenases and terminal PG synthases. Microsomal prostaglandin...http://www.pnas.org/cgi/content/short/105/32/11110?rss=1 |