Journal of Biology - Most viewed articlesMost viewed articles in last 30 days from Journal of Biology (ISSN 1475-4924) published by BioMed CentralThe Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling- August 7, 2003 Background: Forkhead transcription factors belonging to the FOXO subfamily are negatively regulated by protein kinase B (PKB) in response to signaling by insulin and insulin-like growth factor in Caenorhabditis elegans and mammals. In Drosophila, the insulin-signaling pathway regulates the size of cells, organs, and the entire body in response to nutrient availability, by controlling both cell size and cell number. In this study, we present a genetic characterization of dFOXO, the only...http://jbiol.com/content/2/3/20 |