Journal of Biology - Most viewed articlesMost viewed articles in last 30 days from Journal of Biology (ISSN 1475-4924) published by BioMed CentralSystemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system- April 22, 2008 Background: Cancer treatment with a variety of chemotherapeutic agents often is associated with delayed adverse neurological consequences. Despite their clinical importance, almost nothing is known about the basis for such effects. It is not even known whether the occurrence of delayed adverse effects requires exposure to multiple chemotherapeutic agents, the presence of both chemotherapeutic agents and the body's own response to cancer, prolonged damage to the blood-brain barrier, inflammation.http://jbiol.com/content/7/4/12 How chemotherapy damages the central nervous system- April 22, 2008 Chemotherapy adversely affects cognitive function both acutely and chronically, but little is known about the underlying mechanisms. A new study shows that short-term chemotherapy causes not only acute injury to progenitor cells, but also delayed damage to myelin.http://jbiol.com/content/7/4/11 Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance- April 15, 2008 Background: Insulin and insulin-like growth factors (IGFs) signal through a highly conserved pathway and control growth and metabolism in both vertebrates and invertebrates. In mammals, insulin-like growth factor binding proteins (IGFBPs) bind IGFs with high affinity and modulate their mitogenic, anti-apoptotic and metabolic actions, but no functional homologs have been identified in invertebrates so far. Results: Here, we show that the secreted Imaginal morphogenesis protein-Late 2 (Imp-L2)...http://jbiol.com/content/7/3/10 |