BMC Chemical Biology - Latest articlesThe latest articles from BMC Chemical Biology (ISSN 1472-6769) published by BioMed CentralEnhancement of intracellular -tocopherol levels in cytokine-stimulated C3H 10T12 fibroblasts: relation to NO synthesis, isoprostane formation, and toc- July 3, 2007 Background: Stimulation of C3H 10T12 murine fibroblasts with interferon-(IFN) and bacterial lipopolysaccharide (LPS) generates reactive oxygen and nitrogen species leading to DNA damage, lipid oxidation, and tocopherol oxidation. The tocopherols possess unique chemical and biological properties that suggest they have important roles related to intracellular defense against radical-mediated damage. Results: Despite increased levels of reactive oxidants and decreased media tocopherol, cellular...http://www.biomedcentral.com/1472-6769/7/2 |