Journal of Inflammation - Most viewed articlesMost viewed articles in last 30 days from Journal of Inflammation (ISSN 1476-9255) published by BioMed CentralTreatment of experimental colitis in mice with LMP-420, an inhibitor of TNF transcription- March 10, 2008 Background: LMP-420 is a boronic acid-containing purine nucleoside analogue that transcriptionally inhibits TNF production but is non-cytotoxic to TNF-producing cells. Methods: This study investigated the efficacy of LMP-420 as an anti-inflammatory agent in acute and chronic colitis induced by oral administration of dextran sulfate sodium (DSS) to mice and in chronic colitis following piroxicam administration to IL-10-deficient mice. The severity of colon inflammation was assessed...http://www.journal-inflammation.com/content/5/1/4 |