Journal of Inflammation - Most viewed articlesMost viewed articles in last 30 days from Journal of Inflammation (ISSN 1476-9255) published by BioMed CentralJNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin- May 29, 2008 Background: Bee venom therapy has been used to treat inflammatory diseases including rheumatoid arthritis in humans and in experimental animals. We previously found that bee venom and melittin (a major component of bee venom) have anti-inflammatory effect by reacting with the sulfhydryl group of p50 of nuclear factor-kappa B (NF-B) and IB kinases (IKKs). Since mitogen activated protein (MAP) kinase family is implicated in the NF-B activation and inflammatory reaction, we further investigated...http://www.journal-inflammation.com/content/5/1/7 |